Grapeseed is an agricultural settlement dedicated to providing San Andreas with its food. Most of the area consists of large fields of crops and livestock along with barns, sheds, and silos containing the necessary equipment to maintain the crops. Fieldmasters are a common sight in Grapeseed along with the smaller Tractors. McKenzie Field is located just to the east of the town and was probably used to store Cropdusters before it was bought by Trevor Philips.

In the western end of the settlement, there is a main road used for commerce and businesses with some residences along the southwest side. The stores are mostly just hardware stores, a Limited Gasoline gas station, and a clothing store. In the southeast, just south of Union Road (technically outside the community), there is a large grain storage facility with large tanks full of grain. Near the storage facility are a few abandoned buildings that form a rail terminus. A cluster of liquor stores is located at the southeastern edge of the community.

The rural town stays true to its slogan and is mostly meant for agriculture or labor.

Despite this, Grapeseed is no different from the nearby town, Sandy Shores, in terms of crime and drug dealing. It is said that the workers in Grapeseed also make amphetamine and distribute it, respectively. Some of the crops being grown also somewhat resemble cannabis, the plant smoked as marijuana.